In vivo, in vitro and in silico methods
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Jurgen Mensch; Julen Oyarzabal; Claire Mackie; Patrick Augustijns
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Article
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2009
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John Wiley and Sons
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English
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The inability of molecules to permeate the BBB is a significant source of attrition in Central Nervous System (CNS) drug discovery. Given the increasing medical drivers for new and improved CNS drugs, small molecule transfer across the BBB is attracting a heightened awareness within pharmaceutical i