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in vivo identification and monitoring of changes in rat brain glucose by two-dimensional shift-correlated 1h nmr spectroscopy

✍ Scribed by M. Peres; O. Fedeli; B. Barrere; B. Gillet; G. Berenger; J. Seylaz; J-C. Beloeil

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 381 KB
Volume: 27
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910270216

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✦ Synopsis

Abstract

Intracerebral glucose resonance was directly detected and resolved in vivo by two‐dimensional shift‐correlated (COSY) ^1^H NMR spectroscopy in anesthetized rats (n = 4). The relative changes in brain glucose concentration were measured by volume integration of the α‐D‐glucose cross peak in the 2D COSY spectra. This report demonstrates the possibility of monitoring the variations in cerebral glucose following iv injection of glucose.

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