𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo growth inhibition of leukemia by 4-amidinoindan-1-one 2′-amidinohydrazone (CGP 48664a), a new inhibitor of S-adenosylmethionine decarboxylase

✍ Scribed by Bernard Dorhout; Roelf Jakob Te Velde; Harri Ferwerdaanneke W. Kingma; Elly De Hoog; Frits A. J. Muskiet

Book ID
102277925
Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
391 KB
Volume
61
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-I-one 2'-amidinohydrazone (CGP 48664A). LI2IO-bearing DBA-2 mice were treated with increasing CGP 48664A doses from I day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after which all mice were killed. CGP 48664A caused dose-related exponential decreases of L I 2 I 0 cell numbers and spermidine and spermine contents. Putrescine contents increased exponentially. Polyamine changes in spleen and liver were less profound. LIZ10 growth inhibition

📜 SIMILAR VOLUMES

in vivo effects of 4-amidinoindan-l-one
in vivo effects of 4-amidinoindan-l-one 2′-amidinohydrazone (CGP 48664A) and α-difluoromethylornithine (DFMO) on L1210 growth, cell-cycle phase distribution and polyamine contents
✍ Bernard Dorhout; Roelf Jakob Te Velde; Harri Ferwerda; Anneke W. Kingma; Elly de 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 558 KB

## Abstract We studied the in vivo effects of 4‐amidinoindan‐l‐one 2′‐amidinohydrazone (CGP 48664A), α‐difluoromethylornithine (DFMO) and a combination of CGP 48664A‐DFMO on tumor growth, cell‐cycle phase distribution and polyamine contents. DBA‐2 mice were inoculated i.p. with 10^5^ L1210 cells on