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4-Amidinoindan-1-one 2′-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition

✍ Scribed by Bernard Dorhout; Marinca F.G Odink; Elly de Hoog; Anneke W Kingma; Eveline van der Veer; Frits A.J Muskiet

Book ID: 117481463
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 300 KB
Volume: 1335
Category: Article
ISSN: 0304-4165
DOI: 10.1016/s0304-4165(96)00134-1

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In vivo growth inhibition of leukemia by

In vivo growth inhibition of leukemia by 4-amidinoindan-1-one 2′-amidinohydrazone (CGP 48664a), a new inhibitor of S-adenosylmethionine decarboxylase

✍ Bernard Dorhout; Roelf Jakob Te Velde; Harri Ferwerdaanneke W. Kingma; Elly De H 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 391 KB

We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-I-one 2'-amidinohydrazone (CGP 48664A). LI2IO-bearing DBA-2 mice were treated with increasing CGP 48664A doses from I day after i.p. L1210 cell inoculation. Treatment was continued