In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies
β Scribed by Ali Mahtabifard; Robert E. Merritt; Reiko E. Yamada; Ronald G. Crystal; Robert J. Korst
- Book ID
- 114058981
- Publisher
- CTSNet
- Year
- 2003
- Tongue
- English
- Weight
- 445 KB
- Volume
- 126
- Category
- Article
- ISSN
- 1097-685X
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## Abstract ## Background We previously demonstrated that a new lentiviral vector derived from nonpathogenic simian immunodeficiency virus (SIVagm) was efficient and safe for longβlasting retinal gene transfer, and that it provided the significant therapeutic effect of expressing human pigment epi
## Abstract ## Background Efficient gene transfer to bone marrow derived mesenchymal stem cells (MSC) would provide an important opportunity to express potent anticancer agents in the tumour microenvironment because of their contribution to the tumour stroma. ## Methods HIVβbased lentiviral vect