In vivo experimental model of human gingival mucosa using immunodeficient mice
โ Scribed by K. Tsukinoki; Y. Miyoshi; T. Aoki; K. Karakida; Y. Ohta; A. Kaneko; Y. Ueyama; Y. Watanabe
- Book ID
- 111261112
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 988 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-3484
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We have developed a liver metastatic model of human colon cancer using severe combined immunodeficient (SCID) mice. Liver metastases were observed in all the SCID mice on day 28 after intrasplenic injection with 5 X lo6 dissociated tumor cells of COL-2-JCK, a human colon cancer strain serially trans
Studies on liver metastasis of human colon cancer are limited because of a lack of suitable animal models. In this study, the usefulness of mice with severe combined immunodeficiency (SCID), which congenitally lack functional T and B lymphocytes, was evaluated in comparison with currently available