✦ LIBER ✦

In vivo evaluation of the reproducibility of T1 and T2 measured in the brain of patients with multiple sclerosis

✍ Scribed by H.B.W. Larsson; P. Christiansen; I. Zeeberg; O. Henriksen

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 661 KB
Volume: 10
Category: Article
ISSN: 0730-725X
DOI: 10.1016/0730-725x(92)90009-o

No coin nor oath required. For personal study only.

✦ Synopsis

The precision (reproducibility) of relaxation times derived from magnetic resonance images of patients with multiple sclerosis (MS) were investigated. Measurements of 10 MS patients were performed at 1.5 T on two occasions within 1 wk. T1 and T2 was measured using a partial saturation inversion recovery sequence (6 points) and a Carr-Purcell-Meiboom-Gill phase alternating-phase shift multiple spin-echo sequence with 32 echoes. Regions of interest (ROI) were placed both in apparently normal white matter and plaques. The precision (+/- 1.96 SD) and the confidence intervals for T1 and T2 for white matter and plaques were calculated. The precision of T1 for white matter and plaques was respectively +/- 94 msec and +/- 208 msec. The precision of T2 for white matter and plaques was respectively +/- 18 msec and +/- 26 msec. For all measurements the coefficient of variation was about 9%. Judging from our own study and others as well, a precision better than 10% for T1 and T2 would seem unrealistic at present.

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