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In vivo evaluation of absorption and excretion of pentylenetetrazol-10-14c from sustained-release and nonsustained-release tablets

✍ Scribed by William R. Ebert; Robert W. Morris; Susan G. Rowles; Henry T. Russell; Gordon S. Born; John E. Christian

Publisher: John Wiley and Sons
Year: 1970
Tongue: English
Weight: 527 KB
Volume: 59
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600591008

No coin nor oath required. For personal study only.

✦ Synopsis

Since many antiarrhythmic agents seem to possess some degree of local anesthetic action, those compounds, namely, Id, IIb, IIIa, and IIIb, were tested for local anesthetic activity. Table is the summary of the results of the testing. Due to the limited number of tests, the data in this table were not analyzed statistically to determine if the average percent anesthesia of the compounds was significantly higher than that of procaine. Therefore, the results should be treated qualitatively rather than quantitatively. It is not surprising that Compounds IIb, IIIa, and IIIb showed local anesthetic activity, because in addition to structural similarity these compounds had a pKa value very close to that of procaine.

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