𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo evaluation of 4-[123I]iodo-N-{2-[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl}benzamide, a potential SPECT radioligand for the 5-HT1A receptor

✍ Scribed by M. Vandecapelle; F. De Vos; H. Vermeirsch; G. De Ley; K. Audenaert; D. Leysen; R.A. Dierckx; G. Slegers


Book ID
117687733
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
123 KB
Volume
28
Category
Article
ISSN
0969-8051

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis and preliminary in vivo evalua
✍ M. Vandecapelle; F. Dumont; F. De Vos; K. Strijckmans; D. Leysen; K. Audenaert; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB 👁 1 views

## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)

In vivo binding of [123I]4-(2′-methoxy p
✍ Mei-Ping Kung; Zhi-Ping Zhuang; Dana Frederick; Hank F. Kung 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 862 KB

The in vivo regional distribution and pharmacological profile of a novel iodinated phenylpiperazine derivative, [12311p-MPPI (4-(2'-methoxy-)phenyl-l-[2'-(N-2"pyridinyl)-p-iodobenzamido-Iethyl-piperazine), in the rat brain were evaluated for use as a potential in vivo imaging agent for 5-HTlA recept

Synthesis, radiosynthesis and preliminar
✍ P. Blanckaert; M. Vandecapelle; L. Staelens; I. Burvenich; R. A. Dierckx; G. Sle 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 106 KB 👁 1 views

## Abstract Many people suffer from psychiatric illnesses like depression and anorexia. Relevant to these diseases is amongst others a malfunctioning of brain 5‐HT~2A~‐receptors. To allow __in vivo__ quantification of these receptors with Single Photon Emission Computerized Tomography (SPECT), a ra

Preparation of N(1-ethyl-2-pyrrolidyl-me
✍ Maria Teresa Cardoso; Philippe Pradelles 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 194 KB

## Abstract We describe the preparation of ^125^I labelling with a higher specific radioactivity of N(1‐ethyl ‐2‐pyrrolidyl‐methyl)2‐ methoxy ‐5‐ethyl sulfonyl benzamide, a potent biological analogue for sulpiride. The incorporation of iodine in the molecule was achieved by the substitution of arom