To study the long-term effect of 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) on the DNAbinding activity of nuclear transcription factors; a single dose of TCDD was injected intraperitoneally to male guinea pigs (1 lg/kg i.p.). The animals were killed after 1, 2, 10, 20, 28, and 40 days, and DNA-bindin
In vivo effects of Panax ginseng extracts on the cytochrome P450-dependent monooxygenase system in the liver of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed guinea pig
β Scribed by Hyung-Chul Lee; Sang-Gu Hwang; Young-Gu Lee; Hyung-Ok Sohn; Dong-Wook Lee; Seok-Youn Hwang; Yi-Swong Kwak; Jae-Joon Wee; Woo-Hong Joo; Yong-Kweon Cho; Ja-Young Moon
- Book ID
- 117173590
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 134 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0024-3205
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## Abstract 2,3,7,8βTetrachlorodibenzoβpβdioxin (TCDD) was classified by the International Agency for Research on Cancer as a carcinogen in humans. It acts through an aryl hydrocarbon receptorβmediated mechanism, inducing the transcription of numerous genes, including various cytochrome P450s (CYPs
The metabolism of pentachlorophenol has been studied in the rat after pretreatments with phenobarbital, 3-methyl cholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In addition to the previously identified metabolite, tetrachloro-p-hydroquinone, trichloro-p-hydroquinone has been identified i