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In-vivo effects of itraconazole on hepatic mixed-function oxidase

โœ Scribed by Damanhonri, Z.; Gumnbleton, M.; Nicholls, P. J.; Shaw, M. A.


Book ID
124066356
Publisher
Oxford University Press
Year
1988
Tongue
English
Weight
370 KB
Volume
21
Category
Article
ISSN
0305-7453

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This study was done to determine the relationship between microsomal lipid peroxidation during hepatic ischemia/reperfusion and alteration in cytochrome P-450-dependent drug metabolism. Rats were pretreated with a-tocopherol to inhibit lipid peroxidation or with vehicle (soybean oil) and then subjec