## Abstract In this study [2‐^13^C] γ‐aminobutyric acid (GABA) was spectrally resolved in vivo and detected simultaneously with [4‐^13^C]glutamate (Glu) and [4‐^13^C]glutamine (Gln) in the proton spectra obtained from a localized 40 μL voxel in rat neocortex with the use of an adiabatic ^1^H‐observ
In vivo detection of 13C isotopomer turnover in the human brain by sequential infusion of 13C labeled substrates
✍ Scribed by Shizhe Li; Yan Zhang; Maria Ferraris Araneta; Yun Xiang; Christopher Johnson; Robert B. Innis; Jun Shen
- Book ID
- 113726491
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 828 KB
- Volume
- 218
- Category
- Article
- ISSN
- 1090-7807
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Resolved localized nuclear magnetic resonance (NMR) signals of 1 H bound to 13 C label in the carbon positions of glutamate C4, C3 and glutamine C4, C3, as well as in aspartate C3, lactate C3, alanine C3, ␥-aminobutyric acid C3, and glucose C1 were simultaneously observed in spectra obtained from ra
## Abstract Localized, water‐suppressed ^1^H‐[^13^C]‐NMR spectroscopy was used to detect ^13^C‐label accumulation in cerebral metabolites following the intravenous infusion of [1,6‐^13^C~2~]‐glucose (Glc). The ^1^H‐[^13^C]‐NMR method, based on adiabatic RF pulses, 3D image‐selected in vivo spectros