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In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

โœ Scribed by Steffen Jung; Derya Unutmaz; Phillip Wong; Gen-Ichiro Sano; Kenia De los Santos; Tim Sparwasser; Shengji Wu; Sri Vuthoori; Kyung Ko; Fidel Zavala; Eric G. Pamer; Dan R. Littman; Richard A. Lang


Book ID
117723258
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
290 KB
Volume
17
Category
Article
ISSN
1074-7613

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## Abstract Dendritic cells (DC) generated after a shortโ€term exposure of monocytes to IFNโ€ฮฑ and GMโ€CSF (IFNโ€DC) are highly effective in inducing crossโ€priming of CD8^+^ T cells against viral antigens. We have investigated the mechanisms responsible for the special attitude of these DC and compared