In Vivo Delivery to Tumors of DNA Complexed with Linear Polyethylenimine
โ Scribed by Coll, Jean-Luc; Chollet, Patrice; Brambilla, Elisabeth; Desplanques, Dominique; Behr, Jean-Paul; Favrot, Marie
- Book ID
- 123610496
- Publisher
- Mary Ann Liebert
- Year
- 1999
- Tongue
- English
- Weight
- 460 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1043-0342
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Background Efยฎcient and target-speciยฎc in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biological ยฏuids and extracellular matrix, and
Background Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Methods Linear or branched polyethylenimine (PEI)/DNA complexes were generated