In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome
โ Scribed by Bonvini, Paolo; Nguyen, Phuongmai; Trepel, Jane; Neckers, Leonard M
- Book ID
- 110061179
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 487 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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## Background: Neurotrophins mediate their effects by binding to members of the trk family of receptor tyrosine kinases and to the low-affinity nerve growth factor receptor p75. nerve growth factor (ngf) has been demonstrated to support survival and differentiation of neuroblastoma (nb) cells by ac
## Abstract The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can