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Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors

โœ Scribed by Alfred L. Goldberg; Tatos N. Akopian; Alexei F. Kisselev; Do Hee Lee


Book ID
110242273
Publisher
Springer
Year
1997
Tongue
English
Weight
86 KB
Volume
24
Category
Article
ISSN
0301-4851

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Addition of the synthetic glucocorticoid, dexamethasone (Dex) to serum-deprived C 2 C 12 myotubes elicited time-and concentration-dependent changes in Nmethylhistidine (3-MH), a marker of myofibrillar protein degradation. Within 24 h, 100 nM Dex significantly decreased the cell content of 3-MH and i