In vivo cisplatin resistance of rat ascites hepatoma AH66
β Scribed by Tomoyoshi Minamino; Masaaki Nomura; Mitsuo Tamai; Shuzo Moritani; Tohru Ohshima; Ken-ichi Miyamoto
- Book ID
- 117468320
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 337 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0304-3835
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A daunorubicin (DNR)-resistant variant (AH66DR) of alpha-fetoprotein (AFP)-producing rat ascites hepatoma AH66 was established. AH66DR was 169 times more resistant to DNR than AH66. A growth-inhibitory effect due to the decrease in sugar uptake following treatment of the cell lines with specific ant
## Abstract Cell clones producing low amounts of alphaβfetoprotein were isolated from AH66 cell line from an ascites hepatoma producing high amounts of AFP __in vitro__. The growth rate and the chromosome constitution were compared between clones producing high and low amounts of AFP. No significan