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In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo

✍ Scribed by Pembe Issamou Mayengue; Mathieu Ndounga; Matondo Maya Davy; Ntsonde Tandou; Francine Ntoumi

Book ID
116181720
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
89 KB
Volume
95
Category
Article
ISSN
0001-706X

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The development in Plasmodium falciparum of the resistance to chloroquine (CQ) constitutes a public health priority, due to its direct influence in childhood mortality. The molecular basis for CQ resistance (CQR) is still unclear but, recently, a new relevant gene, named pfcrt, with several point mu

Relationship between the Pfcrt T76 and t
Relationship between the Pfcrt T76 and the Pfmdr-1 Y86 mutations in Plasmodium falciparum and in vitro/in vivo chloroquine resistance in Burkina Faso, West Africa
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The relationship between Pfcrt T76 and Pfmdr-1 Y86 mutations in Plasmodium falciparum was explored in samples from patients with uncomplicated malaria and tested in vitro and in vivo with chloroquine (CQ) in Burkina Faso. The two mutations were strongly related. The Pfcrt T76 mutation was found in 8