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In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer

โœ Scribed by Tupper, J; Stratford, M R; Hill, S; Tozer, G M; Dachs, G U


Book ID
109842689
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
542 KB
Volume
17
Category
Article
ISSN
0929-1903

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We have previously proposed the horseradish peroxidase (HRP) and the non-toxic plant hormone indole-3-acetic acid (IAA) as a novel system for gene-directed enzyme/prodrug therapy (GDEPT). The cytotoxic potential of HRP/IAA GDEPT and the induction of a bystander effect were demonstrated in vitro unde