✦ LIBER ✦

Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid

✍ Scribed by Greco, Olga; Folkes, Lisa K; Wardman, Peter; Tozer, Gillian M; Dachs, Gabi U

Book ID: 110017770
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 411 KB
Volume: 7
Category: Article
ISSN: 0929-1903
DOI: 10.1038/sj.cgt.7700258

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Mechanisms of cytotoxicity induced by ho

Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy

✍ Olga Greco; Gabi U. Dachs; Gillian M. Tozer; Chryso Kanthou 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

We have previously proposed the horseradish peroxidase (HRP) and the non-toxic plant hormone indole-3-acetic acid (IAA) as a novel system for gene-directed enzyme/prodrug therapy (GDEPT). The cytotoxic potential of HRP/IAA GDEPT and the induction of a bystander effect were demonstrated in vitro unde

In vivo characterization of horseradish

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer

✍ Tupper, J; Stratford, M R; Hill, S; Tozer, G M; Dachs, G U 📂 Article 📅 2010 🏛 Nature Publishing Group 🌐 English ⚖ 542 KB

Analysis of the horseradish peroxidase/i

Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a three-dimensional tumor model

✍ Tupper, Joanna; Greco, Olga; Tozer, Gillian M; Dachs, Gabi U 📂 Article 📅 2004 🏛 Nature Publishing Group 🌐 English ⚖ 199 KB

Gene-directed enzyme prodrug therapy for

Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease

✍ Rosetta Martiniello-Wilks; Allison Dane; Dale J. Voeks; Geetha Jeyakumar; Elin M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 310 KB 👁 1 views

## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar