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In vivo cervical cancer growth inhibition by genetically engineered cytotoxic T cells

โœ Scribed by Peter Dall; Isabell Herrmann; Bettina Durst; Mariam A. Stoff-Khalili; Gerd Bauerschmitz; Bettina Hanstein; Dieter Niederacher

Book ID
105966798
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
580 KB
Volume
54
Category
Article
ISSN
0340-7004

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Melanoma-specific T-cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T-cells to inhibit growth of human melanoma xenografts by using a Winn assay. Nude mice receiving specific CTLs (n = 1