𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In-vivo behaviour of hypodermically implanted microfabricated glucose sensors

✍ Scribed by M. Koudelka; F. Rohner-Jeanrenaud; J. Terrettaz; E. Bobbioni-Harsch; N.F. de Rooij; B. Jeanrenaud

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
605 KB
Volume
6
Category
Article
ISSN
0956-5663

No coin nor oath required. For personal study only.

✦ Synopsis

The in-vivo behaviour of microfabricated GOD (glucose oxidase)/H2O2 glucose sensor implanted subcutaneously in normal anaesthetized rats has been studied. The sensor consists of a planar, three-electrode microcell, an enzyme membrane (glucose oxidase and bovine serum albumin cross-linked with glutaraldehyde) and an outer diffusion limiting polyurethane membrane. The sensor behaviour during hyperglycaemic (13.8 mM and 11.2 mM), euglycaemic (7.8 mM) and hypoglycaemic (3.5 mM) plateau levels was determined. The values of the in-vivo sensitivity (0.64 +/- 0.05 nA/mM) and background current (1.25 +/- 0.4 nA) were determined using a two-point calibration method and then used to calculate apparent subcutaneous glucose concentrations. The results show the presence of a good correlation between all the plasma glucose levels (G) and the apparent subcutaneous tissue concentrations (G'), with G' = 0.997.G - 0.066, r = 0.9782.

πŸ“œ SIMILAR VOLUMES

In vivo evaluation of an electroenzymati
In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue
✍ K.W. Johnson; J.J. Mastrototaro; D.C. Howey; R.L. Brunelle; P.L. Burden-Brady; N πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 563 KB

Cleanroom processing techniques have been used to mass-produce flexible, electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro characterization studies have shown the sensor's performance to be acceptable. Initial in vivo studies were conducted with the sensor i

In vitro and in vivo evaluation of oxyge
In vitro and in vivo evaluation of oxygen effects on a glucose oxidase based implantable glucose sensor
✍ Yanan Zhang; George S. Wilson πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 699 KB

The oxygen effect on a glucose oxidase based implantable glucose sensor was investigated based on studies of tissue oxygen availability and demand for oxygen by the glucose sensor. In vitro measurements showed that the oxygen effect is directly related to the glucose sensor sensitivity and linearity

Microfabrication technology of flexible
Microfabrication technology of flexible membrane based sensors for in vivo applications
✍ Richard P. Buck; Vasile V. Cosofret; Erno Lindner; Stefan Ufer; Marcel B. Mudara πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 830 KB

Potentiometric ion-sensitive planar microelectrode arrays, and amperornetric enzyme-containing biosensors were fabricated by photolithographic microelectronic technology on a flexible polyimide substrate. The steps of the microelectronics processing are summarized in more detail than previously desc

In vivo molecular sensing in diabetes me
In vivo molecular sensing in diabetes mellitus: an implantable glucose sensor with direct electron transfer
✍ J. C. Pickup; G. W. Shaw; D. J. Claremont πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 534 KB

Miniature, amperometric glucose sensors were constructed for implantation in the subcutaneous tissue of normal and insulin-dependent diabetic subjects. To minimise dependence on fluctuating tissue oxygen tension, we employed the technology of mediated electron transfer, with 1,1'-dimethylferrocene a

In vitro and in vivo characterization of
In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors
✍ H. E. Koschwanez; F. Y. Yap; B. Klitzman; W. M. Reichert πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 702 KB

## Abstract The purpose of this study was to test the hypothesis that porous poly‐L‐lactic acid (PLLA) sensor coatings reduce fibrosis and promote blood microvessel formation in tissue adjacent to the sensor surface. Porous PLLA coatings were produced using ammonium bicarbonate as the gas foaming/s