𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vivo Assessment of the Impact of Efflux Transporter on Oral Drug Absorption Using Portal Vein-Cannulated Rats

✍ Scribed by Matsuda, Y.; Konno, Y.; Hashimoto, T.; Nagai, M.; Taguchi, T.; Satsukawa, M.; Yamashita, S.

Book ID
121868133
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2013
Tongue
English
Weight
984 KB
Volume
41
Category
Article
ISSN
0090-9556

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

N-(3,4-dimethoxyphenethyl)-4-(6,7-dimeth
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a β€œchemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat
✍ Amit S. Kalgutkar; Kosea S. Frederick; Jonathan Chupka; Bo Feng; Sarah Kempshall πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 193 KB

The utility of the diaminoquinazoline derivative CP-100,356 as an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat. CP-100,356 was devoid of inhibition (IC 50 >50 mM) against major human P450 enzymes including P4503A4. In human MDR1-transfected MDCKII cells,

Effect of short-, medium-, and long-chai
Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats
✍ Suzanne M. Caliph; William N. Charman; Christopher J.H. Porter πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 256 KB πŸ‘ 2 views

The contribution of lymphatic transport and absorption directly into the portal blood to the overall oral bioavailability of a model lipophilic drug, halofantrine (Hf), was determined in lymph-cannulated, conscious, unrestrained rats after administration in lipidic vehicles with different fatty acid

In Vitro absorption and secretory quotie
In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates
✍ Victoria E. Thiel-Demby; Timothy K. Tippin; Joan E. Humphreys; Cosette J. Serabj πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 92 KB πŸ‘ 1 views

The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com