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Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans

โœ Scribed by Hurst, Susan; Loi, Cho-Ming; Brodfuehrer, Joanne; El-Kattan, Ayman


Book ID
120288306
Publisher
Informa plc
Year
2007
Tongue
English
Weight
493 KB
Volume
3
Category
Article
ISSN
1742-5255

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โœ Daniel R. Mudra; Jin Y. Jin; Ronald T. Borchardt ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 528 KB

The absorption of drug molecules is often investigated using in vitro or in situ models of the intestinal mucosa; however, few studies have quantified the kinetics that limit absorption. The objective of this study was to quantify kinetic rates of rat intestinal absorption, metabolism, and efflux us