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In vivo assessment of myocardial blood flow in rat heart using magnetic resonance imaging: Effect of anesthesia

✍ Scribed by Isabelle Iltis; Frank Kober; Christiane Dalmasso; Carole Lan; Patrick J. Cozzone; Monique Bernard

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
310 KB
Volume
22
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To assess the influence of isoflurane and pentobarbital anesthesia and the carrier gases on myocardial blood flow (MBF) in the rat heart in vivo.

Materials and Methods

MBF was quantified in vivo using arterial spin‐labeling (ASL) magnetic resonance imaging (MRI). Left ventricular (LV) function was estimated during the same experiment using cine‐MRI. Thirty‐four male Wistar‐Kyoto rats were divided in four groups, one anesthetized with isoflurane in oxygen:nitrous oxide mix (ISO), the three others with intraperitoneal pentobarbital, and breathing either room air (PB), oxygen:nitrous oxide (PB + N~2~O), or oxygen:nitrogen (PB + N~2~).

Results

MBF was significantly higher in the ISO and PB + N~2~O groups vs. PB and in ISO vs. PB + N~2~, with the following respective MBF values: ISO, 5.9 ± 1.1; PB, 4.0 ± 0.8; PB + N~2~O, 5.1 ± 1.4; and PB + N~2~, 4.6 ± 0.8 mL/g/minute, mean ± SD. Ejection fractions were reduced by 10% in PB and PB + N~2~O rats vs. ISO rats. Cardiac output (CO) and index (CI) were 25 to 30% lower in all rats anesthetized with pentobarbital than with isoflurane.

Conclusion

Isoflurane and nitrous oxide induce a higher MBF than pentobarbital. Isoflurane also induces a higher ejection fraction in healthy rats. J. Magn. Reson. Imaging 2005;22:242–247. © 2005 Wiley‐Liss, Inc.

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