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In vivo assessment of catechol O-methyltransferase activity in rabbit skeletal muscle

✍ Scribed by Takafumi Fujii; Toji Yamazaki; Tsuyoshi Akiyama; Shunji Sano; Hidezo Mori


Book ID
116266485
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
211 KB
Volume
111
Category
Article
ISSN
1566-0702

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A non-radiometric method to measure the catechol-0-methyltransferase (COMT) activity in erythrocytes was modified to increase its sensitivity four-fold as well as its reproducibility and applicability. The method is based on the COhlT-mediated O-methyiation of 44naphtho [1,2-d] thiazol-2-yl) pyrocat