In vivo and in vitro antiinflammatory activity of a lipid compound from Sideritis javalambrensis P.

✍ Scribed by A. J. Godoy; B. de las Heras; J. M. Vivas; A. M. Villar

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 85 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(1998)12:1+<s111::aid-ptr267>3.0.co;2-q

✦ Synopsis

A lipid compound was isolated from a hexane antiinflammatory extract of the Spanish herb Sideritis javalambrensis Pau. It was evaluated for antiinflammatory activity in vivo and in vitro. This compound prevented carrageenan-induced inflammation in rats, acting on the exudate and also reducing the number of leukocytes. Modifications of neutrophil enzyme secretion (b-glucuronidase) in vitro may contribute to its antiinflammatory profile.