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In vivo and ex vivo displacement of zinc from metallothionein by cadmium and by mercury

โœ Scribed by Frances A. Day; Allen E. Funk; Frank O. Brady

Book ID
113136805
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
862 KB
Volume
50
Category
Article
ISSN
0009-2797

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โœ Peter Coyle; Geralt Niezing; Tanya L. Shelton; Jeffrey C. Philcox; Allan M. Rofe ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 168 KB

The protective role of metallothionein (MT) in Cd-mediated hepatotoxicity was investigated in vivo and in vitro. Following injection of Cd (2 mg/kg, intraperitoneal or subcutaneous) hepatoxicity was significantly greater at 20 h in metallothionein-null (MT -/-) mice, compared with controls (MT+/+).