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Displacement of zinc and copper from copper-induced metallothionein by cadmium and by mercury: In vivo and ex vivo studies

โœ Scribed by Allen E. Funk; Frances A. Day; Frank O. Brady

Book ID
113379406
Publisher
Elsevier Science
Year
1987
Weight
655 KB
Volume
86
Category
Article
ISSN
0306-4492

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โœ Peter Coyle; Geralt Niezing; Tanya L. Shelton; Jeffrey C. Philcox; Allan M. Rofe ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 168 KB

The protective role of metallothionein (MT) in Cd-mediated hepatotoxicity was investigated in vivo and in vitro. Following injection of Cd (2 mg/kg, intraperitoneal or subcutaneous) hepatoxicity was significantly greater at 20 h in metallothionein-null (MT -/-) mice, compared with controls (MT+/+).