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In vivo activities of the new anthelmintic depsipeptide PF 1022A

✍ Scribed by Georg von Samson-Himmelstjerna; Achim Harder; Thomas Schnieder; Jochen Kalbe; Norbert Mencke

Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
124 KB
Volume
86
Category
Article
ISSN
1432-1955

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πŸ“œ SIMILAR VOLUMES

Synthesis, conformational studies and an
Synthesis, conformational studies and anthelmintic activity of a constrained PF1022A analogue
✍ Scherkenbeck, JΓΌrgen; Dyker, Hubert; Gondol, Daniel; Harder, Achim; Plant, Andre πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 179 KB πŸ‘ 2 views

A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF1022A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the conΓΌrmation of this analogue is both rigidiΓΌed and distorted compared with the asymmetric conformation of PF1022A

Ionophore and Anthelmintic Activity of P
Ionophore and Anthelmintic Activity of PF 1022A, a Cyclooctadepsipeptide, Are Not Related
✍ Geßner, Guido; Meder, Sabine; Rink, Thomas; Boheim, GΓΌnther; Harder, Achim; Jesc πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 841 KB

PF 1022A, a 24-membered cyclooctadepsipeptide and a potent anthelmintic drug, is active against nematodes but not against arthropods. Muscle cells of Ascaris suum generate autorhythmic spikes in electrophysiological control experiments. Exposure of the worm to PF 1022A leads to flaccid paralysis and

Anthelmintic Actions of the Cyclic Depsi
Anthelmintic Actions of the Cyclic Depsipeptide PF1022A and its Electrophysiological Effects on Muscle Cells of Ascaris suum
✍ Martin, Richard J.; Harder, Achim; Londershausen, Michael; Jeschke, Peter πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 606 KB

The cyclic depsipeptide PF1022A, givea orally to mice, showed very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spwnosa at 50 mg kg-'. In uitro, PF1022A was very active against Trichinella spiralis and had good activity against Nippostrongylus brasiliensis at 1 pg d-'.