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A highly efficient synthesis of the anthelmintic cyclooctadepsipeptide PF1022A

✍ Scribed by Jürgen Scherkenbeck; Andrew Plant; Achim Harder; Norbert Mencke

Publisher: Elsevier Science
Year: 1995
Tongue: French
Weight: 856 KB
Volume: 51
Category: Article
ISSN: 0040-4020
DOI: 10.1016/0040-4020(95)00461-g

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

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A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF1022A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the conürmation of this analogue is both rigidiüed and distorted compared with the asymmetric conformation of PF1022A