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In vivo [11C]dihydrotetrabenazine binding in rat striatum: sensitivity to dopamine concentrations

โœ Scribed by Michael R. Kilbourn; Elizabeth R. Butch; Timothy Desmond; Phillip Sherman; Paul E. Harris; Kirk A. Frey

Book ID
116799376
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
224 KB
Volume
37
Category
Article
ISSN
0969-8051

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We have previously shown that tracer concentrations of [llC]cocaine binding to the dopamine transporter (DAT) in human and baboon striatum can be visualized using positron emission tomography (PET). To determine whether the concentration of dopamine normally present in the synaptic cleft can compete