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In vitro transmission of chromosomal aberrations through mitosis in human lymphocytes

โœ Scribed by F.S Pala; J.E Moquet; A.A Edwards; D.C Lloyd

Book ID
114070329
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
74 KB
Volume
474
Category
Article
ISSN
0027-5107

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Post-treatment of mutagen-treated human peripheral lymphocytes with a single-strand specific endonuclease from Neurospora crassa leads to a significant elevation of the rate of structural chromosomal aberrations. Our results indicate that DNA double-strand breaks (DSB) are ultimate lesions for the f