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In vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens

✍ Scribed by DIPAOLO, J. A.; NELSON, R. L.; DONOVAN, P. J.

Book ID
109681440
Publisher
Nature Publishing Group
Year
1972
Tongue
English
Weight
342 KB
Volume
235
Category
Article
ISSN
0028-0836

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The Syrian hamster embryo (SHE) cell transformation model has been used by many investigators to study the multistep process of neoplastic transformation induced by chemical carcinogens. In this study we have attempted to determine if activated proto-oncogenes are present in the transformed cells in

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Phenolphthalein is a cathartic agent widely used in nonprescription laxatives. For the simultaneous assessment of in vitro carcinogenicity and mutagenicity of phenolphthalein, the ability of this chemical to induce cell transformation and genetic effects was examined using the Syrian hamster embryo