In vitro toxicity of 7H-dibenzo[c,g]carbazole in human liver cell lines
✍ Scribed by T. O'Brien; J. Schneider; D. Warshawsky; K. Mitchell
- Book ID
- 117587506
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 286 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0887-2333
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7H-dibenzo[c,g]carbazole (DBC) is a potent liver and skin carcinogen when topically applied to the back skin of mice. This compound is found in complex mixtures produced during incomplete combustion of fossil fuels as well as in wood and tobacco smoke. The objective of this study was to elucidate th
Parenchymal (PC) and nonparenchymal (NPC) liver which is exclusively hepatocarcinogenic, were anacells have different tissue-specific, procarcinogen lyzed in parallel. Both PC and NPC generated the activation enzymes. NPC appear to be protected ultimate metabolites of DBC, but NPC were substanagains