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In vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia

✍ Scribed by M. Nowicki; D. Ostalska-Nowicka; B. Miskowiak

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
187 KB
Volume
32
Category
Article
ISSN
0145-2126

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✦ Synopsis

The aim of the present research was to investigate the possible in vitro stimulatory effect of substance P (SP) on blasts induction in childhood common acute lymphoblastic leukaemia (ALL). Bone marrow aspirates were incubated with SP receptor agonist or antagonist (spantide) and subsequently assayed for the presence of human interleukin (IL)-1b using ELISA kit.

Blast cells incubated with SP receptor agonist were found to result in a significant increase of IL-1b concentration while incubated with spantide resulted in control levels of IL-1b. These findings suggest the novel possible role of SP in blasts proliferation in childhood ALL of common (CD10) origin.

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Significance of common acute lymphoblast
Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission
✍ S. E. Self; S. Morgan; O. Grush; M. F. La Via πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 339 KB

Bone marrows from 21 children with acute lymphoblastic leukemia in complete remission (CR) and off therapy for 14 months to 10 years were examined by flow cytometry with a panel of monoclonal antibodies. Significant percentages of CALLA+ cells of low fluorescence intensity were present up to 9 years