Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission

✍ Scribed by S. E. Self; S. Morgan; O. Grush; M. F. La Via

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 339 KB
• Volume: 8
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/hon.2900080204

✦ Synopsis

Bone marrows from 21 children with acute lymphoblastic leukemia in complete remission (CR) and off therapy for 14 months to 10 years were examined by flow cytometry with a panel of monoclonal antibodies. Significant percentages of CALLA+ cells of low fluorescence intensity were present up to 9 years after CR. These results emphasize the need to interpret flow cytometry results in light of the findings that low intensity CALLA + cells represent a normal population of immature, non-malignant lymphoid cells.