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In vitro study of intestinal transport of fluoride using the Caco-2 cell line

✍ Scribed by Rocha, R.A.; Devesa, V.; Vélez, D.

Book ID
120497750
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
395 KB
Volume
55
Category
Article
ISSN
0278-6915

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi