In vitro study of Fc-receptor function in autoimmune diseases
✍ Scribed by D. Roccatello; J.C. Bensa; R. Coppo; C. Rollino; M. Diaz; G. Martina; G. Piccoli
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 270 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0165-2478
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Multiple lines of evidence implicate cytokines in the pathogenesis of autoimmune and inflammatory diseases. Neutralization of the biological activities of cytokines by interfering with ligand binding to specific cell-surface cytokine receptors thus represents an approach to controlling such diseases
## Abstract A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized ^51^Cr‐labeled autologous erythrocytes from the circ