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In Vitro Study of Dexamethasone Release From Poly(p-xylylene) Films

✍ Scribed by Phillip Hanefeld; Seema Agarwal; Rakesh Kumar; Andreas Greiner

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 294 KB
Volume: 211
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.200900537

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Stents or metal endoprotheses are currently used to prevent restenosis after percutaneous transluminal angioplasty (PTA). Recently multi‐component systems comprising implant applications, e. g., stents, protective and/or a drug containing layers, have found wide‐spread application. Permanent and biocompatible stent coatings based on poly(p‐xylylene) (PPX) films were investigated for their potential to form drug containing reservoirs. The model drug dexamethasone was loaded into films of PPX by solvent treatment. Loading efficiency and in vitro drug release profiles were studied under physiological conditions. Linear release of dexamethasone was observed when PPX/dexamethasone films were coated by an additional PPX film as cover layer.

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