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In vitro studies on drug-antibiotic interactions I: Analgesics, antipyretics, antimalarials, and tranquilizers

✍ Scribed by Mohamed A. Toama; Hamed M. el Fatatry; Bahgat el Falaha

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
398 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

The antimicrobial effects of some analgesics, antipyretics, antimalarials, and tranquilizers were determined. The phenothiazines were the most active group. The effect of the chosen drugs when combined with a selected number of antibiotics was studied on Staphylococcus aureus and Escherichia coli to determine the type of interaction. Most analgesics, antipyretics, and antimalarials showed either no effect or a synergistic action. However, some exhibited antagonistic effects. All tested tranquilizers were synergistic. Preliminary studies, using electronic absorption spectrometry, indicated that the antagonistic action may be attributed to a physical interaction.

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