Microsealed drug delivery systems I: In vitro-in vivo correlation on subcutaneous release of desoxycorticosterone acetate and prolonged hypertensive animal model for cardiovascular studies
✍ Scribed by Yie W. Chien; Leonard F. Rozek; Howard J. Lambert
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 426 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
A new generation drug delivery system, named the Microsealed Drug Delivery (MDD) system, was developed. Subcutaneous implantation of MDD's in rats for up to 129 days resulted in a constant release profile of desoxycorticosterone acetate. Three formulations were examined. An excellent i n uitro-in uiuo correlation was established on both the mechanism and the rate of controlled release of desoxycorticosterone acetate from MDD's. A significant degree of hypertension was reproducibly produced within 21 days after implantation and successfully sustained through Day 98. Comparative studies were conducted on MDD's and a previously developed matrix-type silicone device. The elevation of systolic blood pressure initiated by either MDD's or the matrix-type silicone device was essentially the same in pattern, and the difference in the hypertensive responses between these polymeric drug delivery systems was statistically insignificant, although a higher dose, which is time dependent, was administered to rats through the mattixtype silicone device than through MDD's. The bioavailability of desoxycorticosterone acetate and its dose-response relationship apparently were accomplished more effectively via the constant drug delivery mechanism of MDD's.
Keyphrases 0 Drug delivery systems, microsealed-subcutaneous release of desoxycorticosterone acetate in rats, i n uitro-in uiuo correlation, compared to matrix-type silicone device Desoxycorticosterone acetate-subcutaneous release from microsealed drug delivery system in rats, i n uitro-in uiuo correlation, compared to matrix-type silicone device 0 Dosage forms-microsealed drug delivery system, subcutaneous release of desoxycorticosterone acetate in rats, in uitro-in uiuo correlation, compared to matrix-type silicone device Adrenocortical steroidsdesoxycorticosterone acetate, subcutaneous release from microsealed drug delivery system in rats, in uitro-in uiuo correlation, compared to matrix-type silicone device