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In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine

✍ Scribed by Giampietro Viola; Giorgia Miolo; Daniela Vedaldi; Francesco Dall’Acqua


Book ID
114019570
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
298 KB
Volume
55
Category
Article
ISSN
0014-827X

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The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI wer