The administration of retinoids has been demonstrated to be of potential utility in the therapy of a wide spectrum of neoplastic pathologies due to the ability to induce differentiation in a large variety of primary tumor cells as well as in vitro cultured cell lines. Moreover, a number of compounds
In vitro sensitivity of CFU-L to cytosine arabinoside (Ara-C)
β Scribed by Marie, J. P. ;Zittoun, R.
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 211 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0098-1532
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High doses of Cytosine-arabinoside (Ara-C) (1 to 3gm/mz every 12 hours during 48 hours) were administered monthly to 5 acute myeloid leukemia patinets during complete remissions subsequent to relapses and reinduction treatment. Plasma Ara-C was measured using a radioimmunoassay and exhibited kinetic
## Abstract Eleven patients with acute lymphocytic leukemia in relapse were treated with Lβasparaginase and cytosine arabinoside (1βΞ²βDβarabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 1