## Abstract ## Background. Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the
In vitro radiation resistance among cell lines established from patients with squamous cell carcinoma of the head and neck
✍ Scribed by Reidar Grénman; Thomas E. Carey; Kenneth D. McClatchey; John G. Wagner; Kirsi Pekkola-Heino; Donald R. Schwartz; Gregory T. Wolf; Leonard P. Lacivita; Laurence Ho; Shan R. Baker; Charles J. Krause; Allen S. Lichter
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 652 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0008-543X
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Gm, A2m, and Km allotypic markers were examined in 40 Caucasian patients with squamous cell carcinomas of the head and neck. Serum IgA levels, the A2m(l) allotypic marker, and antibodies against IgAl, A2m(l), and A2m(2) were measured quantitatively. The frequency of Km(1) was found to be significant
## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##
Genomic instability in simple repeated sequences has been observed in several human cancers. We have analyzed 50 squamous cell carcinomas of the head and neck (SCCHN) and 5 pre-malignant severe dysplastic tissues from Indian patient populations for microsatellite instability in 18 different loci spr