In vitro properties of a chitosan-bonded self-hardening paste with hydroxyapatite granules

✍ Scribed by Maruyama, Masaaki ;Ito, Michio

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 638 KB
• Volume: 32
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199612)32:4<527::aid-jbm5>3.0.co;2-t

✦ Synopsis

A new self-hardening paste was made by using a combination of chitosan, hydroxyapatite (HA) granules, ZnO, and CaO. The sol was made by dissolving 0.1 g of chitosan in a solution of 0.1 g malic acid and 2.0 mL physiological saline solution. Mixed with 0.03 g of CaO and 0.04 g of ZnO powders was 2.77 g (55 wt "/.) of HA granules which had a homogeneous pore distribution and a porosity of 3548%. The size of the granules was set for 0.1-0.3 mm. Kneading and setting of the paste generated a little amount of heat (32.8"C) as compared with the heat produced by polymethylmethacrylate (PMMA) bone cement (114.5"C). The pH value of chitosan-HA-hardened composite after setting was nearly