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In vitro properties of a chitosan-bonded bone-filling paste: Studies on solubility of calcium phosphate compounds

✍ Scribed by Ito, M. ;Yamagishi, T. ;Yagasaki, H. ;Kafrawy, A. H.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 392 KB
Volume: 32
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(199609)32:1<95::aid-jbm11>3.0.co;2-h

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✦ Synopsis

The present study investigated properties of various mixtures of organic acids (malic and malonic) and calcium phosphate compounds (beta-tricalcium phosphate, ashed bovine bone, and synthetic hydroxyapatite) with the objective of determining the optimum combination of organic acid and calcium phosphate compound for components of a chitosan-bonded bone-filling paste. beta-tricalcium phosphate was decomposed by malic acid and malonic acid, but these two acids did not decompose synthetic hydroxyapatite and ashed bovine bone. Assessment of ion release from a set paste containing either synthetic hydroxyapatite or ashed bovine bone indicated that only calcium ions were appreciably released after storing and stirring the set paste in physiologic saline for 7 days.

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