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In vitro photoperoxidation as an indicator of the potential phototoxicity of non-steroidal anti-inflammatory 2-arylpropionic acids

✍ Scribed by Miranda, M.A.; Castell, J.V.; Gómez-Lechón, M.J.; Martinez, L.A.


Book ID
122956124
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
373 KB
Volume
7
Category
Article
ISSN
0887-2333

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Phototoxicity of non-steroidal anti-infl
✍ J.V. Castell; M.J. Gómez-Lechón; M.A. Miranda; I.M. Morera 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 793 KB

In this work, the phototoxicity of two non-steroidal anti-inflammatory drugs, Butibufen and Flurbiprofen, was examined. Both were unstable to light, to give several photoproducts which were isolated and identified. The different photoproducts were formed by a primary photochemical mechanism which in