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In Vitro Pharmacology of GS-5759, a Phosphodiesterase 4 Inhibitor and 2 Agonist


Book ID
125457256
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
59 KB
Volume
349
Category
Article
ISSN
0022-3565

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Interspecies in vitro metabolism of the
โœ Kevin P. Bateman; Laird Trimble; Nathalie Chauret; Jose Silva; Stephen Day; Dwig ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 174 KB

## Abstract Lโ€454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies __in vitro__ metabolism data was generated usin