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In vitro pharmacological evaluation of the dichloromethanol extract from Schinus molle l.

✍ Scribed by R. Bello; B. Beltrán; L. Moreno; S. Calatayud; E. Primo-Yúfera; J. Esplugues

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
99 KB
Volume
12
Category
Article
ISSN
0951-418X

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✦ Synopsis

The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 mg/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 mg/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholineinduced contractions (NS). No significant effect was found with a 1 mg/mL dose.

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